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Mechanisms of GLP-1 Receptor Agonists in HFpEF: Exploring Weight-Dependent and Independent Drivers of Therapeutic Benefit | Circulation: Heart Failure

69,75 Based on the primary efficacy outcome from this study - that is, change in glycated haemoglobin A1C (HbA1c) from baseline to 26 weeks - the SURPASS clinical phase III trials (A phase of tirzepatide [LY3298176] in participants with type 2 diabetes not controlled with diet and exercise alone (SURPASS-1)

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This raised the question of whether CFTR-expressing cells can be proliferating