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In addition to oxidative stress, local inflammation mediated by proinflammatory cytokines, such as interleukin–6 (IL-6), tumor necrosis factor-alpha (TNF-α), IL-18, can cause direct damage to the renal cells and can lead fibrosis via extracellular matrix accumulation
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Fever above 100.4 degrees Fahrenheit combined with UTI symptoms suggests pyelonephritis, a kidney infection that requires aggressive treatment
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