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Triiodothyronine (T3) increases fatty acid oxidation and energy expenditure, influences cholesterol metabolism, but however has off-target effects of cardiac hypertrophy and tachycardia, as well as systemic muscle wasting and bone resorption [144], [153], [157], [160], [45]

DHEA

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This location was chosen in clinical trials because it provides consistent subcutaneous absorption and reliable drug delivery into the tissue layer beneath the skin