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In pre-clinical models, GLP-1 secretion from enteroendocrine L cells is upregulated via toll-like receptor 4 (TLR4) activation in response to increased lipopolysaccharide (LPS) translocation, secondary to impaired barrier function
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It’s generally safe to combine fibre supplements with gentle osmotic laxatives, but always space them apart by at least 2 hours and consult your healthcare provider for personalised advice.
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