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Not because anyone wants a quarter of weight loss to come from muscle, but because that's roughly what happens when humans go into negative energy balance without targeted intervention

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Key findings relevant to the split-dose question: From SURMOUNT-1 (Jastreboff et al., NEJM 2022): Nausea rates were dose-dependent: 21% at 5 mg, 25% at 10 mg, 31% at 15 mg