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450 Budesonide, a synthetic second-generation corticosteroid drug with strong local anti-inflammatory activity, can significantly ameliorate inflammatory damage and oxidative stress 451 and improve rectal bleeding and diarrhea

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There was also a twofold increase in vasodilatory capacity in patients treated with saxagliptin versus placebo, signifying an improvement in the eye vasculature, although the increase was nonsignificant