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Importantly, these medications carry boxed warnings for medullary thyroid carcinoma risk and are contraindicated in patients with personal or family history of MEN2 or medullary thyroid carcinoma

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Across 37 randomised trials and 3,048 participants with type 2 diabetes, it lowered fasting plasma glucose by 0.82 mmol/L (95% CI 0.95 to 0.70 lower), roughly 15 mg/dL, and HbA1c by 0.63 percentage points (Xie and colleagues, Frontiers in Pharmacology, 2022)