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Retatrutide’s simultaneous glucagon receptor engagement adds GCGR-driven cAMP signalling in hepatocytes and adipocytes, triggering phosphorylation of hormone-sensitive lipase, upregulation of uncoupling protein 1 (UCP1) in brown adipose tissue, and activation of peroxisome proliferator-activated receptor alpha (PPARα) pathways
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Together, these medications provide robust HbA1c reduction with minimal hypoglycaemia risk, making them particularly valuable for patients requiring treatment intensification beyond metformin-based therapy
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