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Chemical Structure Technical Specifications The peptide contains two non-coded amino acid residues (aminoisobutyric acid) at positions 2 and 13, which significantly reduce susceptibility to dipeptidyl peptidase-4 (DPP-4) degradation

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As a result, patients with conditions leading to low albumin levels are not at risk of additional changes to the semaglutide pharmacokinetics in IcoSema