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Shedding excess body weight can significantly reduce intra-abdominal pressure, a crucial factor in minimizing the risk of hernia recurrence

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Furthermore, a new orally bioavailable GLP-1RA, oral hypoglycemic peptide 2 (OHP2), can confer protective effects on diabetic cardiomyopathy through rescuing cardiac lipotoxicity by inhibiting Rho (the small GTPase) kinase (ROCK)/PPARα pathway 89 , 90 (Figure 1)