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The cardiac benefits of GLP-1 agonists were not anticipated before outcome studies were performed for several reasons: (1) Historical Precedent-past experiences with other diabetes medications that unexpectedly had adverse cardiovascular effects made it less likely for researchers and clinicians to anticipate potential cardiovascular benefits without concrete evidence from large-scale trials

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Key Takeaways Magnesium deficiency is common on GLP-1 therapy: Reduced food intake cuts daily magnesium by 40% or more