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Moreover, the levels of 5-hydroxytryptamine, γ-aminobutyric acid (GABA) and their receptors, as well as glutamate receptors are reduced in patients with AD (42–46)
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Whether this pattern persists beyond 52 weeks, whether it is dose-dependent, and whether it is reversible upon discontinuation of therapy are questions that remain unanswered and need to be addressed in larger, longer-duration trials
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