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Blood monocytes differentiate into several types of macrophages: classically activated types (M1) are pro-inflammatory and anti-fibrogenic, whereas alternatively activated M2 types are anti-inflammatory, pro-fibrogenic, and induce M1 cell apoptosis through IL-10 (Kazankov et al., 2019)
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Designed with the main purpose of controlling type 2 diabetes, they’ve now emerged as powerful tools for managing obesity and potentially preventing heart disease, kidney failure, and even Alzheimer’s
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