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Experimental studies have indicated that GLP-1RA (liraglutide) treatment in mice with endotoxemia increases survival and decreases inflammatory markers (monocyte chemoattractant protein-1 (MCP-1 or chemokine (C-C motif) ligand 2 or CCL2), TNF-α, inducible nitric oxide synthase or iNOS, intercellular adhesion molecule 1 or ICAM-1 and vascular cell adhesion molecule-1 or VCAM-1) in leukocytes and endothelial cells (ECs) and vascular dysfunction [51,52]
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GLP-1s were originally developed to help manage Type 2 diabetes, but they are now commonly prescribed for weight loss
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