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Funnels plot of the reduction in DHEAS, SHBG, total testosterone, free testosterone and FAI levels indicated no publication bias (Fig

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Neither showed any effect on the primary endpoint, the Clinical Dementia Rating-Sum of Boxes at 104 weeks, nor on secondary cognitive and functional scales, and a pooled analysis found no delay in progression from mild cognitive impairment to dementia (hazard ratio 0.96) [1]