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Toujeo specifically enters the picture when a patient needs basal insulin and either has already tried and failed GLP-1 therapy, has a contraindication to GLP-1 drugs, has Type 1 diabetes, or has very advanced Type 2 diabetes with negligible beta cell function

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Reducing Glucagon Secretion: GLP-1 inhibits the secretion of glucagon, a hormone that increases blood sugar levels by promoting the release of glucose from the liver