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64 A study from 2015 hypothesized that, by acting on SIRT6, diabetes may enhance the inflammatory potential of atherosclerotic plaques, favoring their instability, and evaluated the effect of incretin therapy in diabetic patients on SIRT6 expression in carotid plaques and early outgrown circulating endothelial progenitor cells (EPCs), it found that compared with nondiabetic plaques, diabetic plaques had more inflammation and oxidative stress, along with a lesser SIRT6 expression and collagen content
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Kevin Jones explains that GLP-1s help reduce appetite, slow digestion, and quiet “food noise.” Medical supervision matters because dosing, side effects, muscle loss, and long-term maintenance need to be monitored
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