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elegans by regulating the mTOR signaling pathway and suppressing the release of CCL11 cytokines, which are connected to age-related cellular and tissue impairments (Thakkar et al., 2013
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For example, at the cellular level, primary neuronal cells from GLP-1R KO and WT mice could be cultured, and the levels of cAMP and changes in downstream phosphorylation of PKA and CREB signaling pathway after GLP-1R agonist treatment could be tested
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