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Volcano plot visualization of GLP-1–MK-801 relative to vehicle revealed transcripts associated with glutamatergic signalling, such as Grin2a , Grin2b , Shisa6 and Slc17a7 among the most differentially upregulated genes (Fig
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The SURMOUNT-1 trial for tirzepatide showed average weight loss of 15 to 22 percent of body weight across the full study population
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