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The first 30 and 29 amino acids of tirzepatide were modeled for the tirzepatide–GIPR–G s and tirzepatide–GLP-1R–G s complexes, respectively

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Examples include pancreatic beta-cell lines (e.g., INS-1, MIN6) for studying insulin secretion, adipocyte cell lines (e.g., differentiated 3T3-L1 cells) for investigating lipid metabolism and adipokine secretion, or hypothalamic neuronal cell lines for exploring central signaling pathways