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doi: 10.3389/fendo.2026.1858420 Received 17 April 2026 Revised 19 June 2026 Accepted 19 June 2026 Published 06 July 2026 Volume 17 - 2026 Edited by Srinivas Mummidi, Texas A&M University San Antonio, United States Reviewed by Raylene A

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GLP-1s may help metabolism and inflammation, but they do not appear to reach the core tissue-level biology of Alzheimer’s: network breakdown, regional vulnerability, and collapse of cellular ecosystems