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GLP-1 and Its Receptor: From Gut Peptide to Central Nervous System (CNS) Signaling GLP-1 is an incretin hormone produced primarily in the intestinal L-cells and, to a lesser extent, by preproglucagon-expressing neurons in the NTS of the brainstem [3,9]

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Because semaglutide improves glucose regulation, individuals with prediabetes or insulin resistance often see favorable changes in blood sugar levels, which can reduce long-term diabetes risk