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The dose-response relationship and tolerance question ADHD stimulant weight loss follows a dose-response curve up to a threshold, then plateaus: Adderall immediate-release dose-response data (from FDA prescribing information and post-marketing studies): 5 to 10 mg daily: 2 to 4 lbs average loss 15 to 20 mg daily: 5 to 8 lbs average loss 25 to 30 mg daily: 7 to 11 lbs average loss 40+ mg daily: 8 to 12 lbs average loss (plateau effect) Above 30 to 40 mg daily, additional dose increases produce minimal additional weight loss