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As GLP-1R agonists have been approved for T2D and obesity [1], appear potentially efficacious in NASH [89], and exhibit cardioprotection in humans with T2D at risk of or with established cardiovascular disease [90], will a GLP-1:GIP co-agonist fully recapitulate all of the benefits ascribed to GLP-1R agonism (Figure 2)

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As previously mentioned, the FDA has included Wegovy in the list of medications currently in shortage, making it challenging to find a pharmacy that has it in stock