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In the 2 months after initiation of semaglutide, the patient’s potassium level dropped to an average of 4.4 (range 4.1–4.6) mmol/L (Figure 2)

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What We’re Pretending We actually know: These drugs affect the brain’s reward system—that’s how they work Many users report reduced cravings for food, alcohol, nicotine, and other substances Some users report emotional blunting, anhedonia, and personality changes Clinical trials excluded psychiatric populations, limiting what we can conclude The studies contradict each other badly enough to justify concern Novo Nordisk has made enough money to buy a small country and is now working on a medium-sized one What we’re pretending to know is a better question