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Important gene mutation types in monogenic obesity PATHOGENIC MECHANISMS AND CLINICAL MANIFESTATIONS OF MC4R -DEFICIENT OBESITY Numerous genetic screening studies in cohorts with severe early-onset obesity have confirmed that obesity due to MC4R deficiency is currently the most common cause of monogenic obesity, highlighting the critical role of MC4R in energy balance regulation [21-24]

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Recentemente, surgiu a tirzepatida, um agonista duplo dos receptores de GLP-1 e GIP (polipeptídeo insulinotrópico dependente de glicose), com resultados promissores tanto em controle glicêmico quanto na redução de peso (WHARTON et al., 2023)