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It further builds on the growing evidence demonstrating the benefits of semaglutide across a range of chronic conditions and has the potential to help even more Canadian patients and their families." About ESSENCE 4 ESSENCE is a phase 3 trial evaluating the effect of once-weekly subcutaneous semaglutide 2.4 mg in adults with metabolic dysfunction-associated steatohepatitis with moderate to advanced liver fibrosis (stage 2 or 3)

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The triple agonism produces weight loss through three coordinated mechanisms: appetite reduction and slowed gastric emptying from GLP-1, amplified satiety from GIP, and increased energy expenditure plus hepatic fatty acid oxidation from glucagon