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Specifically, the GLP-1 co-secreted cousin PYY(1-36), agonist of the vasoconstrictive Y(1) receptor, is physiologically trimmed by DPP-IV to give rise to the appetite-suppressant, anti-diabetic and blood-brain barrier permeable PYY(3-36) agonist of Y(2) receptor (220)
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Why Side Effects Are Usually Worse at the Beginning The dose escalation schedule used with GLP-1 medications is specifically designed to reduce side effect burden by allowing the body time to adapt before the dose increases
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