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Specifically IPRA (0.1–3 mg/kg), PIO (3–30 mg/kg), IPRA (1 mg/kg) combined with PIO (10 mg/kg), or a vehicle were given orally to diabetic mice with NASH for 4 weeks
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The genus Berberis (Berberidaceae) exhibits substantial interspecific and intraspecific variation in berberine concentration, heavily dependent on the specific plant organ analyzed
