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Exenatide (a GLP-1 receptor agonist) rapidly lowered intracranial pressure in active IIH, with a sustained signal at 12 weeks and no meaningful weight change. The authors suggest an ICP-lowering mechanism beyond weight
Treatment with the transcription inhibitor actinomycin D blocks GLP-1 stimulation of GLUT1 and hexokinase1 expression in these cells without affecting GLP-1 induction of insulin expression [464]
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Globally, the GLP-1 receptor agonist market is experiencing robust growth, with a valuation of USD53.46 billion in 2024
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