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The valine metabolite 3-HIB promotes trans-endothelial fatty acid transport and ectopic lipid accumulation within skeletal muscle, contributing to local lipotoxicity and insulin resistance (23, 91)

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In plain terms, it nudges your hormones to help you feel full sooner and use glucose more effectively — a mechanism that clinicians and trial data (the SURPASS and SURMOUNT programs) have shown to produce meaningful improvements in A1c and body weight