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However, novel dual receptor agonists have been developed for the treatment of obesity and T2D under the concept that GLP-1 restrains the hyperglycemic action of glucagon, while allowing it to exert its beneficial actions on bodyweight, food intake, lipid metabolism and thermogenesis ( One month-therapy with a pegylated GLP-1R/GCGR dual agonists in diet-induced obese (DIO) mice resulted in bodyweight loss and improved glycemic control
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