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CONCLUSIONS Our findings support the American Diabetes Association recommendations to avoid combination therapy with GLP-1 RA and DPP-4 inhibitors.2 Moderate improvements in glycemic control without clinically significant weight loss are the likely outcomes of concomitant GLP-1 RA and DPP-4 inhibitor treatment, regardless of dosing frequency.9,11 Additionally, the clinical improvements reflect the effects GLP-1 RA and are not potentiated by the combination