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Preclinical studies in obese and diabetic rodent models suggest that GLP-1 receptor agonists enhance spermatogenesis, hormone profiles, and sperm function through two intracellular signaling pathways: cyclic adenosine monophosphate and protein kinase A (cAMP/PKA), and phosphoinositide 3-kinase and protein kinase B (PI3K/Akt)

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