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Furthermore, Gs utilization in GLP-1R signaling was enhanced by X-box binding protein 1 (XBP1) and activating transcription factor 6 (ATF6)—two key transcription factors involved in endoplasmic reticulum (ER) stress responses, have been shown to selectively enhance Gs signaling through GLP-1R, whereas Gq signaling remains unaffected (Sawada et al., 2020
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Patient adherence may theoretically improve with patch-based delivery, as some individuals find regular injections burdensome or anxiety-provoking
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