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Furthermore, in another meta-analysis [23], which excluded ELIXA [24] due to fact that lixisenatide is a short-acting GLP-1RA and all participants had acute coronary syndrome, GLP-1RAs were associated with significant reductions in MACE (HR 0.85, 95% CI 0.80–0.90), cardiovascular death (HR 0.85, 95% CI 0.78–0.93), stroke (HR 0.81, 95% CI 0.74–0.90), and myocardial infarction (HR 0.88, 95% CI 0.81–0.96) (Table 2)
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The dose is increased by 0.6 milligrams each week until the maintenance dose of 3.0 milligrams is reached
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